POLL: What would u like to try?

[JerkKILLER]

TweetHey guys,

if the following peptides were available domestic,
who would be interested in trying them out at the listed hypothetical prices?


Just curious




** For confidentiality reasons user names will NOT be shown on the poll.
But I'd like you to reply in the thread that "you'd be interested" (if u voted)
so I know how many votes are legit, and which ones are people trying to
be funny **

THX

[bionic redneck]

Tweet

Hey guys,

if the following peptides were available domestic,
who would be interested in trying them out at the listed hypothetical prices?


Just curious




** For confidentiality reasons user names will NOT be shown on the poll.
But I'd like you to reply in the thread that "you'd be interested" (if u voted)
so I know how many votes are legit, and which ones are people trying to
be funny **

THX

i voted for the PT-141... i read some interestin facts about it helpin in the sack.. so that sparked my interest..lol..hey at least i am honest about it..lol.. plus the rest cost more because of the dosage and which ones have to be taken together.. ex. igf and mgf

[iron_dawg]

Tweetnot very familiar with the whole peptide thing haven't had much time to research it...but how close is GHRP to the real thing if anyone could give me there input and maybe someone who has used it before.

[gator_mclusky]

TweetSome need to know what are Peptides and what they do.........

gator

[JerkKILLER]

TweetGood idea Gator, must have slipped my mind.

Some need to know what are Peptides and what they do.........

gator

[JerkKILLER]

TweetHere's the info on PT-141 aka Bremelanotide



Bremelanotide
(pronounced /ˌbrɛməˈlænɵtаɪd/ ( listen)) (formerly PT-141) is a compound under drug development by Palatin Technologies as a treatment for hemorrhagic shock and reperfusion injury. It functions by activating the melanocortin receptors MC1R and MC4R, to modulate inflammation and limiting ischemia. [1] It was originally developed for use in treating sexual dysfunction but this application was discontinued in 2008, after concerns were raised over adverse side effects of increased blood pressure.

Development

Originally, the peptide Melanotan II, that bremelanotide was developed from, was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects.[2]

In studies, bremelanotide was shown to induce lordosis in an animal model [3] and was also effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system. [4]

A Phase III clinical trial was scheduled to begin in the first half of 2007, but was delayed until August 2007. On August 30, Palatin announced that the U.S. Food and Drug Administration had expressed serious concerns regarding the risk/benefit ratio of bremelanotide with regards to the side effect of increased blood pressure. The FDA stated that they would consider alternate uses for bremelanotide, including as a treatment for individuals who do not respond to more established ED treatments. However, On May 13, 2008, Palatin Technologies announced it "has discontinued development of Bremelanotide for the treatment of male and female sexual dysfunction" however they concurrently announced plans to develop it as a treatment for hemorrhagic shock instead. [5] The company additionally announced intentions to focus its attention on another compound, PL-6983, that causes lower blood pressure in animal models. [6]

Structure

Bremelanotide is a cyclic hepta-peptide lactam analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the melanocortin receptors MC3-R and MC4-R in the central nervous system. It has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). It is a metabolite of Melanotan II that lacks the C-terminal amide function.



See also

* Flibanserin
* Intrinsa
* Melanotan II


References

1. ^ Bremelanotide for Organ Protection and Related Indications, Palatin Technologies fact sheet. Retrieved on 2009-01-18.
2. ^ "Tanning drug may find new life as Viagra alternative" (HTML). CNN. 1999. http://www.cnn.com/HEALTH/men/9906/1...a.alternative/. Retrieved on 2007-09-16.
3. ^ Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P (July 2004). "Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10201–4. doi:10.1073/pnas.0400491101. PMID 15226502.
4. ^ Vicki Mabrey (2006). "ABC News "The Business of Desire - Love Potion"" (HTML, Flash Video). ABC News. http://abcnews.go.com/Video/playerIndex?id=2712896. Retrieved on 2009-01-24.
5. ^ "Palatin Technologies announces new strategic objectives and reports third quarter 2008 financial results" (HTML). Palatin Technologies press release. 2008. http://palatin.com/news/news.asp?param=202. Retrieved on 2008-08-21.
6. ^ "Palatin Technologies Announces New Strategic Objectives". http://palatin.com/news/news.asp?ID=201. Retrieved on 2008-05-13.



Other links that may be of interest

* Palatin Technologies The company that developed bremelanotide. http://www.palatin.com/products/brem...e/overview.asp
* US 6,794,489 bremelanotide (PT-141) patent(Appl. No.:040547) http://www.google.com/patents?vid=6794489
* US 6,579,968 bremelanotide (PT-141) patent (Appl. No.:066501) http://www.pharmcast.com/Patents/Yr2...xual061703.htm
* www.melanotan.org

[kingvillan]

TweetI am interested in CJC...I have used IGF and PEG-MGF, PCT when I got off a cycle and took a break from HGH and was interested in how it compared to HGH. I am currently on Hexeralin for post IGF and PEG-MGF. In my experiences, HGH is still the best!