• Amused
  • Angry
  • Annoyed
  • Awesome
  • Bemused
  • Cocky
  • Cool
  • Crazy
  • Crying
  • Depressed
  • Down
  • Drunk
  • Embarrased
  • Enraged
  • Friendly
  • Geeky
  • Godly
  • Happy
  • Hateful
  • Hungry
  • Innocent
  • Meh
  • Piratey
  • Poorly
  • Sad
  • Secret
  • Shy
  • Sneaky
  • Tired
  • Wtf
  • Results 1 to 2 of 2

    Thread: The Identification of Illegal Anabolic Steroids.....

    Hybrid View

    Previous Post Previous Post   Next Post Next Post
    1. #1
      baby1's Avatar
      baby1 is offline Administrator
      Points: 63,737, Level: 100
      Level completed: 0%, Points required for next Level: 0
      Overall activity: 0%
      Achievements:
      Overdrive1000 Experience PointsThree FriendsRecommendation First ClassVeteran
      is the boss lady!!!
       
      I am:
      Happy
       
      Join Date
      Feb 2011
      Posts
      5,324
      Post Thanks / Like
      Points
      63,737
      Level
      100
      Rep Power
      10

      Default The Identification of Illegal Anabolic Steroids.....

      in Customs Seizures by GCMS and High Resolution LCMS

      There have been numerous reports in the news over the last few years of new drugs of abuse becoming available on the UK
      market. These have included mephedrone, benzylpiperazine and the so-called synthetic cannabinoids found in ‘Spice’ type herbal
      high products. These have all led to revisions of the misuse of drugs act in an attempt to control their distribution and use.
      A slightly older problem is the importation of anabolic steroids. In the year 2008/9 there were 802 seizures of anabolic steroids in
      the UK [1]. Of these, 259 were by the Borders Agency and the remainder by the Police forces. The misuse of drugs act now
      includes most known anabolic steroids and a generic wording to include most ‘designer’ anabolic steroids.

      In contrast to previous decades where drugs of abuse were produced domestically or smuggled in to the country, many now arrive in bogusly labeled consignments destined for private addresses in the UK. The UK borders agency
      frequently intercepts shipments of significant size containing unknown white powders. These often do not contain the ‘traditional’ drugs of abuse that are readily identified by technology available at ports of entry to the UK. In such situations, seizures are sent for further analysis at laboratories, typically utilising GCMS, in an attempt to make an identification. This approach is often successful where the drug is amenable to GCMS analysis and a reference mass spectrum exists in a library or publication.
      There are occasions however where the drug is not suitable for analysis by GCMS or no reference spectrum is available. In such circumstances the use of high resolution LCMS can aid in the identification process.
      In recent months, we have been forwarded samples of powders and oils seized by the UK borders agency that could not be identified by GCMS and mass spectral comparison.
      Most have been from shipments of several kilograms of material. We have used LCMS consisting of a ThermoFisher Accela UPLC sytem interfaced to an LTQ Orbitrap to identify several anabolic steroids, all of which are controlled under the misuse of drugs act. We have also identified other steroids using GCMS and in-house databases.
      The powders received for analysis were found to be anabolic steroids, all ofwhich
      are listed as Class C drugs under the Misuse of Drugs Act. The precise origin of
      these powders was unknown, but it is likely that they came from China. They were all destined for private addresses in the UK.
      The use of high resolution LCMS proved to be very useful in the identification of
      these compounds and was certainly complementary to GCMS in that some
      compounds, for example stanozolol and trenbolone were best analysed by LCMS
      whilst others were detected only by GCMS. Where reference spectra did not exist, as with drostanolone propionate, the combination of both techniques led to identification based on the elemental composition derived from accurate mass
      measurement and the similarity of the GCMS derived EI mass spectrum to a
      reference spectrum of another compound.
      The identification of customs seizures of this type can often be limited by databases and this is where the use of accurate mass can assist in giving additional information. As was shown with this work, accurate mass determination, followed
      by the assignment of probable elemental composition, often gives a good starting point in the identification process.

    2. #2
      Bolan's Avatar
      Bolan is offline Platinum Member
      Points: 3,730, Level: 38
      Level completed: 54%, Points required for next Level: 70
      Overall activity: 5.0%
      Achievements:
      Recommendation Second Class1000 Experience PointsVeteran
      is Hung like a mouse
       
      I am:
      Cool
       
      Join Date
      Aug 2009
      Posts
      290
      Post Thanks / Like
      Points
      3,730
      Level
      38
      Rep Power
      15

      Default Re: The Identification of Illegal Anabolic Steroids.....

      Nice read !

    Thread Information

    Users Browsing this Thread

    There are currently 1 users browsing this thread. (0 members and 1 guests)

    Posting Permissions

    • You may not post new threads
    • You may not post replies
    • You may not post attachments
    • You may not edit your posts
    •