Reported Characteristics

  • Active-Life: 10-12 hours
  • Drug Class: Diuretic (Oral)
  • Average Reported Dosage: 50-200mg (total) daily
Spironothiazid is a diureteic and an ALDOSTERONE antagonist. This means thatit suppresses the water retaining actions of the hormone ALDOSTERONE whilelowering water retention by lowering electrolytes (potassium, sodium, and calcium). Theadvantage of the combination is that the potassium absorption effect by thespironolactone can be mediated by the hydrochlorthiazide. Because of this, some of thepotassium loss side effects can be avoided. This is probably a safer choice than LASIXthough any diuretic use should be medically monitored. Thiazides also lead to a lowerloss of calcium.
Side effects are commonly due to imbalances in electrolytes and fluids. They caninclude irregular pulse rate, cramps, and light headiness. Since the drug has ANTIANDROGENICquality (spironolactone), men can experience possible gyno, andimpotence due to higher dosage and/or prolonged use. These were noted to not occur dueto the brief administration period normally employed. According to available literature, itis best to avoid higher potassium intake during use. Dosages were usually 50-150mg aday for no more than 3 days. Dosages were divided into 2-3 daily dosages.