This is just my personal experience. Over the years I've used some research chems that gave me the same results as brand name. I've also used some research chems that I thought were less than par. If you're using a good solid reputable research chem, then I wouldn't think you'd have much to worry about. Same goes with everything really. I think the main reason some people would opt for brand name with anything is just peace of mind. If it says it's 10mg of something, then it's most likely 10mg of that something. However, like I said if you're using a good reputable research chem then I feel you can have that same peace of mind. I usually lean toward research or generic stuff mainly due to price and convenience. Everyone is going to have their own personal preference and reason for having that preference.