The clen makes me shake (just out of control)....They work well together though. Personally, I have never used the t4. Aj would know though...T3 has always been kind to me. I've been using it for years. I also have taken in just about every way that was popular at that given time and always burned fat. Some say cycle up a week then stay there two and come down. That's the way if had the best luck. Your thyroid is nothing to mess with though. Make sure your taking to dose everyday at the same time and don't miss doses and double the next....be smart.