Good points Mr. Clap-

that first paragraph sounds about right to me. One thing you left out though would be that since the arteries are constricted with NSAID use, the kidneys arent getting 100% of the normal blood flow or oxygen that they're suppose to get. If this happens for too long, parts of the kidney will start to die and yes, GFR will take a huge nosedive because of it.

For clarification, he didnt take 2400mg a day for 20yrs. Some days he would take that much and some days he'd take anywhere from 600-1000mg/day on average. There were even some days when he got lucky and didnt need to take any at all.

But still, continued regular use of NSAIDS at least 3-5 days per week over 20yrs would seriously hurt the kidneys IMO.



Quote Originally Posted by theclap View Post
Yeah 20 years of NSAID abuse could definitely do it... I believe. I'm no nephrologist.

That absolutely blows my mind that the docs told him that. But then if it was twenty years ago... maybe they didn't know. As far as I understand it NSAIDs constrict the afferent renal artery and thereby decrease glomerular filtration rate (GFR). Over time this could not only lead to a buildup in creatinine and blood urea nitrogen (the byproduct of protein metabolism) but a permanent reduction in GFR. I'm not positive on that but from memory... that's what I got.

As far as a lawsuit goes? Who knows, could he really prove that they said that? At the time they said it was there research showing that NSAIDs (when abused) could cause kidney damage? If this thing is going to kill him... or significantly shorten his life, and he has a good case it might be worth it so he has some money to leave to his family. But you also have to consider that he would be dealing with lawyers. It's been my experience that lawyers that are "on your side" screw you as hard as the ones that are against you.

Sorry for the ramble. Just my thoughts.